Cambridge, Massachusetts,<\/p>\n
Moderna Inc\u2019s experimental vaccine was 94.5% effective in preventing Covid-19 based on interim data from a late-stage trial, the company said on Monday, becoming the second U.S. drug maker to report results that far exceed expectations.<\/p>\n
Together with Pfizer Inc\u2019s vaccine, which is also more than 90% effective, and pending more safety data and regulatory review, the United States could have two vaccines authorized for emergency use in December with as many as 60 million doses of vaccine available this year.<\/p>\n
Next year, the U.S. government could have access to more than 1 billion doses just from the two vaccine makers, more than needed for the country\u2019s 330 million residents.<\/p>\n
The vaccines, both developed with new technology known as messenger RNA (mRNA), represent powerful tools to fight a pandemic that has infected 54 million people worldwide and killed 1.3 million. The news also comes at a time when Covid-19 cases are soaring, hitting new records in the United States and pushing some European countries back into lockdowns.<\/p>\n
\u201cWe are going to have a vaccine that can stop Covid-19,\u201d Moderna President Stephen Hoge said in a telephone interview.<\/p>\n
Moderna\u2019s interim analysis was based on 95 infections among trial participants who received either a placebo or the vaccine. Of those, only five infections occurred in those who received the vaccine, which is administered in two shots 28 days apart.<\/p>\n
\u201cHaving more than one source of an effective vaccine will increase the global supply and, with luck, help us all to get back to something like normal sometime in 2021,\u201d said Eleanor Riley, professor of immunology and infectious disease at the University of Edinburgh.<\/p>\n
Moderna expects to have enough safety data required for U.S. authorization in the next week or so and the company expects to file for emergency use authorization (EUA) in the coming weeks.<\/p>\n
The company\u2019s shares, which have more than quadrupled this year, rose 15% in premarket trading while European stocks and Wall Street stock futures jumped on the vaccine update. The benchmark S&P 500 futures rose 1.3%, stopping just short of a new record high, while the pan-European STOXX 600 hit late-February highs. [MKTS\/GLOB]<\/p>\n
Shares in Pfizer were down 1.7% in premarket trading while Britain\u2019s AstraZeneca, which has yet to release any results from its late-stage vaccine trials, were 0.7% weaker.<\/p>\n
A key advantage of Moderna\u2019s vaccine is that it does not need ultra-cold storage like Pfizer\u2019s, making it easier to distribute. Moderna expects it to be stable at normal fridge temperatures of 2 to 8 degrees Celsius (36 to 48\u00b0F) for 30 days and it can be stored for up to 6 months at -20C.<\/p>\n
Pfizer\u2019s vaccine must be shipped and stored at -70C, the sort of temperature typical of an Antarctic winter. It can be stored for up to five days at standard refrigerator temperatures or for up to 15 days in a thermal shipping box.<\/p>\n
The data from Moderna\u2019s trial involving 30,000 volunteers also showed the vaccine prevented cases of severe Covid-19, a question that still remains with the Pfizer vaccine. Of the 95 cases in Moderna\u2019s trial, 11 were severe and all 11 occurred among volunteers who got the placebo.<\/p>\n
Moderna, part of the U.S. government\u2019s Operation Warp Speed program, expects to produce about 20 million doses for the United States this year, millions of which the company has already made and is ready to ship if it gets FDA authorization.<\/p>\n
\u201cAssuming we get an emergency use authorization, we\u2019ll be ready to ship through Warp Speed almost in hours,\u201d Hoge said. \u201cSo it could start being distributed instantly.\u201d<\/p>\n
The 95 cases of Covid-19 included several key groups who are at increased risk for severe disease, including 15 cases in adults aged 65 and older and 20 in participants from racially diverse groups.<\/p>\n
\u201cWe will need much more data and a full report or publication to see if the benefit is consistent across all groups, notably the elderly, but this is definitely encouraging progress, said Stephen Evans, professor of pharmacoepidemiology, London School of Hygiene & Tropical Medicine.<\/p>\n
One unknown with this vaccine, and all the others currently being tested, is whether they will stop Covid-19 spreading.<\/p>\n
\u201cIt is likely that vaccines that prevent symptomatic disease will reduce the duration and level of infectiousness, and thus reduce transmission, but we don\u2019t yet know if this effect will be large enough to make any meaningful difference to the spread of the virus within communities,\u201d said Riley at Edinburgh University.<\/p>\n
Most side effects were mild to moderate. A significant proportion of volunteers, however, experienced more severe aches and pains after taking the second dose, including about 10% who had fatigue severe enough to interfere with daily activities while another 9% had severe body aches. Most of these complaints were generally short-lived, Moderna said.<\/p>\n
\u201cThese effects are what we would expect with a vaccine that is working and inducing a good immune response,\u201d said Peter Openshaw, professor of experimental medicine at Imperial College London<\/p>\n
Moderna\u2019s data provide further validation of the promising but previously unproven mRNA platform, which turns the human body into a vaccine factory by coaxing cells to make certain virus proteins that the immune system sees as a threat and mounts a response against.<\/p>\n
The United States has the world\u2019s highest known number of Covid-19 cases and deaths with more than 11 million infections and nearly 250,000 deaths.<\/p>\n
The Trump Administration has primarily relied on the development of vaccines and treatments as its response to the pandemic. Moderna has received nearly $1 billion in research and development funding from the U.S. government and has a $1.5 billion deal for 100 million doses. The U.S. government also has an option for another 400 million doses.<\/p>\n
The company hopes to produce between 500 million and 1 billion doses in 2021, split between its U.S. and international manufacturing sites, dependent in part on demand.<\/p>\n
Moderna also said it would use its data to seek authorization in Europe and other regions.<\/p>\n
Europe\u2019s health regulator said on Monday it had launched a real-time \u201crolling review\u201d of Moderna\u2019s vaccine, following similar reviews of vaccines from Pfizer and AstraZeneca.<\/p>\n
Other countries such as China and Russia have already begun vaccinations. Russia licensed its Sputnik-V Covid-19 vaccine for domestic use in August before it released data from large-scale trials. It said on Nov. 11 that its vaccine was 92% effective based on 20 infections in its large trial.<\/p>\n","protected":false},"excerpt":{"rendered":"
Cambridge, Massachusetts, Moderna Inc\u2019s experimental vaccine was 94.5% effective in preventing Covid-19 based on interim data from a late-stage trial, the company said on Monday, becoming the second U.S. drug maker to report results that far exceed expectations. Together with Pfizer Inc\u2019s vaccine, which is also more than 90% effective, and pending more safety data […]<\/p>\n","protected":false},"author":5,"featured_media":17714,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12,31,1378],"tags":[],"class_list":["post-17713","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","category-news","category-us"],"_links":{"self":[{"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/posts\/17713","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/comments?post=17713"}],"version-history":[{"count":1,"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/posts\/17713\/revisions"}],"predecessor-version":[{"id":17715,"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/posts\/17713\/revisions\/17715"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/media\/17714"}],"wp:attachment":[{"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/media?parent=17713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/categories?post=17713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.vosa.tv\/eng\/wp-json\/wp\/v2\/tags?post=17713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}