CEO Brian Chesky said in a tweet the company would take steps to “combat unauthorized parties and get rid of abusive host and guest conduct”.
“We must do better, and we will. This is unacceptable,” Mr Chesky added.
Five people were killed in the mass shooting on Thursday, which sent around 100 terrified partygoers running for their lives in the San Francisco suburb of Orinda.
All of those who died were under 30.
The four-bedroom home had been rented on Airbnb by a woman who told the owner her dozen family members had asthma and needed to escape smoke from a wildfire, a person with knowledge of the transaction said.
Responding to the mass shooting, California Governor Gavin Newsom called for Congress to pass gun control legislation. “This will barely make the news today. That’s how numb we have become to this,” he said.